Download Advances in Rapid Sex-Steroid Action: New Challenges and New by Gabriella Castoria, Antimo Migliaccio PDF

By Gabriella Castoria, Antimo Migliaccio

Breast and prostate cancers are either hormone-dependent, at the very least in a few levels in their development. Hormonal manipulation represents an enormous healing method. even supposing such a lot of breast and prostate cancers at the beginning reply to hormone remedy, so much tumors reinitiate to development. ultimately, hormone-resistant and metastatic breast and prostate cancers might improve. therefore, the problem is the dissection of mechanisms in which steroid receptor signaling pathways proceed to steer telephone development and invasiveness. Compelling proof exhibits that steroid hormones elicit non-genomic responses in extra-nuclear compartment of objective cells. during this mobile place, steroid-coupled receptors quickly recruit signaling effectors or scaffold proteins and turn on a number of pathways resulting in proliferation, survival, migration and invasiveness. The instant problem is the dissection of key occasions regulating the steroid reaction of aim tissues to avoid development and increase therapy of breast and prostate cancers.

Show description

Read Online or Download Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers PDF

Best cancer books

Palliative Care Consultations in Advanced Breast Cancer (Palliative Care Consultations)

The Palliative Care Consultations sequence is basically aimed toward these participants operating in an acute health center melanoma middle and/or tertiary referral middle. Books are designed to provide the busy clinician suggestion on scientific difficulties, either these infrequently encountered and people who are quite common, yet tough.

Cancer Immunotherapy at the Crossroads: How Tumors Evade Immunity and What Can Be Done (Current Clinical Oncology)

Top investigators and clinicians aspect different mechanisms utilized by tumors to flee and impair the immune method after which spell out attainable scientific innovations to avoid or opposite tumor-induced immune disorder. The authors evaluation the mechanisms of immune disorder and evasion mechanisms in histologically varied human tumors, targeting tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that could function biomarkers for sufferer analysis.

Etiology of Cancer in Man

This quantity reports our present wisdom relating can­ numerous chapters speak about the contributions of genetic asp­ cer development and development because it pertains to the etiology of ects, metabolism, endocrine-related points and meals to human melanoma. As emphasised in Volumes I-V of this sequence, melanoma development.

Breast Cancer: Methods and Protocols

This quantity presents assets, principles, and bench manuals for the research of breast melanoma. This e-book is split into 5 sections: tools utilized in medical laboratory for prognosis (Detection of Molecular Markers of Breast Cancer); tools utilized in either medical and study laboratories for trying out genetic adjustments (Genetic Detection of Breast melanoma) and (Isolation of Breast melanoma Cells); tools used to check the habit of breast melanoma cells (In Vitro Experimental Assays for Breast Cancer); and techniques used for mimicking human breast melanoma in a residing organism (In Vivo Experimental types for Breast Cancer).

Extra info for Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers

Sample text

C-Src has been implicated in colorectal, breast, melanoma, ovarian, gastric, head and neck, pancreatic, lung, brain, and blood cancer development/progression [8], though it is poorly oncogenic on its own. However, mice expressing endogenous c-Src and the polyomavirus middle T antigen transgene under the control of a mammary-specific promoter form more tumors at a faster rate than those expressing polyomavirus middle T on a c-Src null background [24], indicating that c-Src can cooperate with other oncogenic factors to enhance tumorigenicity.

Estrogen-induced ER association with Shc stimulates c-Src-mediated ERK activation. 4. Estrogen increases ER and c-Src association with MNAR and c-Src activation, resulting in ERK phosphorylation and increased transcription from ERE-containing promoters. 5. Estrogen induces the formation of an ER, p130Cas, and c-Src complex, which supports ERK phosphorylation and cyclin D1 expression. 6. The association of AR and c-Src activate ERK through an estrogen and ER-dependent mechanism. 7. Type IV collagen signals through integrins, ER, and c-Src to induce transcription from ERE-containing promoters.

Several small-molecule inhibitors and monoclonal antibodies are currently being tested or used in the clinic for the treatment of these tumors. Keywords Estrogen receptor Á Progesterone receptor Á Androgen receptor Á c-Src Á HER family receptors Á Therapeutic resistance S. J. edu J. E. Pritchard Department of Microbiology, University of Virginia Cancer Center, Charlottesville, VA 22908, USA E. M. Fox Hematology/Oncology Division, Ingram Cancer Center, Vanderbilt University, Nashville, TN 37240, USA M.

Download PDF sample

Rated 4.30 of 5 – based on 35 votes