Download Apoptosis and Cancer Chemotherapy by J. Martin Brown PhD, Bradly G. Wouters PhD (auth.), John A. PDF

By J. Martin Brown PhD, Bradly G. Wouters PhD (auth.), John A. Hickman, Caroline Dive (eds.)

The previous few years have witnessed an awesome foreign attempt that demonstrated the function of a few 20 new molecules in apoptosis and extra activation or suppression of apoptosis to the approved organic capabilities of an outstanding many others already known in melanoma biology. a few of these molecules are receptors, transducing cytokine-mediated signs; others seem to accentuate or curb the chance compro­ mised mobile will fireplace its apoptosis effector mechanism. All are of curiosity as capability objectives for tumor remedy, and a few might turn out to be keep an eye on issues stimulated within the pathogenesis of melanoma and different illnesses as different as viral an infection, neurodegenerative issues, and stroke. occasionally, in the course of those advancements, one of those euphoria ap­ pears to have gripped the learn neighborhood, with the expectancy that apoptosis will manage to pay for factors to many unsolved questions in cellu­ lar rules. This e-book, in a sequence of considerate and provocative ar­ ticles--some from tested leaders within the box, and others from more youthful scientists--seeks to redress the balance.

Show description

Read Online or Download Apoptosis and Cancer Chemotherapy PDF

Best cancer books

Palliative Care Consultations in Advanced Breast Cancer (Palliative Care Consultations)

The Palliative Care Consultations sequence is basically aimed toward these members operating in an acute medical institution melanoma heart and/or tertiary referral middle. Books are designed to provide the busy clinician suggestion on scientific difficulties, either these hardly encountered and those who are quite common, yet tough.

Cancer Immunotherapy at the Crossroads: How Tumors Evade Immunity and What Can Be Done (Current Clinical Oncology)

Major investigators and clinicians aspect the various mechanisms utilized by tumors to flee and impair the immune procedure after which spell out attainable scientific techniques to avoid or opposite tumor-induced immune disorder. The authors evaluation the mechanisms of immune disorder and evasion mechanisms in histologically varied human tumors, targeting tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), which may function biomarkers for sufferer analysis.

Etiology of Cancer in Man

This quantity reports our present wisdom bearing on can­ a number of chapters speak about the contributions of genetic asp­ cer progress and development because it pertains to the etiology of ects, metabolism, endocrine-related elements and foodstuff to human melanoma. As emphasised in Volumes I-V of this sequence, melanoma development.

Breast Cancer: Methods and Protocols

This quantity presents assets, principles, and bench manuals for the examine of breast melanoma. This e-book is split into 5 sections: tools utilized in scientific laboratory for analysis (Detection of Molecular Markers of Breast Cancer); tools utilized in either medical and learn laboratories for checking out genetic adjustments (Genetic Detection of Breast melanoma) and (Isolation of Breast melanoma Cells); tools used to review the habit of breast melanoma cells (In Vitro Experimental Assays for Breast Cancer); and strategies used for mimicking human breast melanoma in a dwelling organism (In Vivo Experimental versions for Breast Cancer).

Additional info for Apoptosis and Cancer Chemotherapy

Sample text

Nature 1993; 362: 847-849. 05. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993; 362: 849-852. 6. Kastan MB, Zhan Qel DW, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ. Mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 1992; 71: 587-597. 07. Waldman T, Lengauer C, Kinzler KW, Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21.

Science 1994; 265: 2091-2093. 70. Lotem J, Sachs L. Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Differ 1993; 4: 41-47. "71. Rupnow BA, Murtha AD, Alarcon RM, Giaccia AJ, Knox SJ. Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy. Cancer Res 1998; 58: 1779-1784. Activation of c-Myc activity in vivo can enhance cellular radiosensitivity through an apoptotic mechanism.

21. Yin DX, Schimke RT. BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells. Cancer Res 1995; 55: 4922-4928. Chapter 1 / Apoptosis and Cell Sensitivity 17 22. Gallardo D, Drazan KE, McBride WHo Adenovirus-based transfer of wild-type p53 gene increases ovarian tumor radiosensitivity. Cancer Res 1996; 56: 4891-4893. 23. Gjerset RA, Sobel RE. Treatment resistance, apoptosis, and p53 tumor suppressor gene therapy. In: Encyclopedia of Cancer, Bertino JR, ed.

Download PDF sample

Rated 4.47 of 5 – based on 47 votes