By Avril D. Woodhead, Claire J. Shellabarger, Virginia Pond, Alexander Hollaender (auth.), Avril D. Woodhead, Claire J. Shellabarger, Virginia Pond, Alexander Hollaender (eds.)
The current workshop had its orlglns in discussions between Alexander Hollaender, Oddvar Nygaard, Donald Borg, Richard Setlow and Victor Bond at the want for a symposium that might care for a large spectrum of urgent matters with regards to the physics, chemistry, and organic activities of ionizing radiations, and the theoretical and sensible difficulties of hazard overview. It quickly grew to become obvious that the spectrum of topics thought of was once too large for the specified intensity of insurance; in reality, it appeared un most likely that the convention individuals may have the heritage wisdom to span the gamut. as a result, separate conferences have been determined upon, the 1st of which, comparability of Mechanisms of Carcinogenesis by means of Radiation and Chemical brokers, used to be held on the nationwide Bureau of criteria, Gaithersburg on December 6-7, 1983. The assembly was once subsidized by means of the NCI. the second one assembly has emerged because the current workshop at Brookhaven nationwide Laboratory. An interface among the 2 meetings has been supplied by means of Michael Fry and Donald Borg, who've summarized the salient issues emanating from the NCI Symposium. We meant that the 1st convention should still concentrate on the elemental mechanisms of radiation and chemical carcinogenesis, whereas the second one, the current assembly, could emphasize exposure-response relationships, quite the theoretical and sensible related ities and alterations among publicity to chemical cancer agents in comparison to publicity to ionizing radiation.
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Extra resources for Assessment of Risk from Low-Level Exposure to Radiation and Chemicals: A Critical Overview
1983, BowmanBirk soybean protease inhibitor as an anticarcinogen, Cancer Res. ), 43:2454s. COMMON MOLECULAR MECHANISMS 37 DISCUSSION Holtzman: Would you care to comment on evidence by Michael Gould and co-workers (Gould, 1984; Mulcahy et al, 1984) and evidence from "so-called" synergistic interactions in our laboratory, that initiation events are much more common then can be deter~ined from the results of carcinogenesis studies. Borg: What is the comparison? Holtzman: tumors. More lesions than you would see expressed as Borg: Yes.
BORG can also give rise to reactive free radical intermediates, so that sometimes the ultimate carcinogens may be free radical metabolites of the carcinogenic chemicals themselves. In other cases autoxidation reactions that are secondary to the metabolism of carcinogens may afford significant fluxes of oxyradicals, including the extraordinarily electrophilic hydroxyl radicals that are the dominant toxic species mediating the indirect effects of radiation damage. On mechanistic grounds, therefore, one might expect this latter class of chemicals to be more radiomimetic in terms of DNA damage and thus, ultimately, in terms of carcinogenic impact as well.
1983, Cooxidation during prostaglandin biosynthesis: a pathway for the metabolic activation of xenobiotics, in: "Reviews in Biochemical Toxicology," p. 135, E. Hodgson, J. R. Bend, and R. M. , New York. , and Salvesen, G. , 1983, Human plasma proteinase inhibitors, Ann. Rev. , 52:655. Ward, J. , 1975, Molecular mechanisms of radiation-induced damage to nucleic acids, Adv. Radiat. , 5:181. The Role of DNA Alkylation in Chemical Carcinogenesis - P. , and Pragnelli, I. , 1983, Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene, Nature (London), 303:72.