By Ann M. Bode, Zigang Dong
Desirous about the invention of particular molecular pursuits for the advance of the melanoma preventive brokers, melanoma Prevention: nutritional components and Pharmacology presents researchers and non-researchers with functional methodologies for constructing and validating small molecule and phytochemical-derived drug discovery and mechanisms wherein those compounds can modulate specific objective proteins concerned about oncogenic signaling. whereas this quantity is basically concentrated towards melanoma prevention study, the variety of ideas verified within the booklet additionally presents an creation of melanoma prevention examine ways to researchers outdoor the sector. Chapters care for a serious dialogue of either laboratory and medical issues, with each one bankruptcy containing either a discursive part in addition to a close equipment part. As a part of the equipment in Pharmacology and Toxicology sequence, this meticulous quantity comprises the type of key implementation recommendation that seeks to make sure winning leads to the lab.
Practical and authoritative, melanoma Prevention: nutritional components and Pharmacology goals to lead study towards choosing molecular objectives and carrying out human experiences with phytochemicals which might, preferably, supply an more advantageous method of the objective of custom-made melanoma prevention.
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Additional info for Cancer Prevention: Dietary Factors and Pharmacology (Methods in Pharmacology and Toxicology)
An initial report showed that 100 % of the C57BL/6J-ApcMin heterozygous mice raised on a high-fat diet developed more than 30 adenomas throughout the intestinal tract and most die by 120 days of age. Heterozygotes also develop anemia [40, 41]. A small number of C57BL/6J-ApcMin heterozygous female mice develop mammary tumors. The Min mutation was discovered in the progeny of a C57BL/6J male mutagenized by ethylnitrosourea. The founding (AKR × C57BL/6J)F1 female displayed circling behavior and was mated to a C57BL/6J male.
Mol Carcinog 45(6):422–430 8. Bode AM, Dong Z (2007) The enigmatic effects of caffeine in cell cycle and cancer. Cancer Lett 247(1):26–39 9. Bode AM, Dong Z (2009) Modulation of cell signal transduction by tea and ginger. In: Surh Y-J, Cadenas E, Dong Z, Packer L (eds) Dietary modulation of cell signaling pathways. Oxidative stress and disease. CRC Press–Taylor & Francis Group, New York, pp 45–74 10. Bode AM, Dong Z (2009) Signal transduction molecules as targets for cancer prevention. Sci Signal 2(59):mr2.
General Methods The potential toxicity of the compound of interest may not be known and therefore the potential toxicity of the compound should be tested in a pilot study using wild type mice. In this case, 24 Ann M. Bode and Zigang Dong mice are divided into four groups and fed vehicle or 1 of 3 amounts of the compound of interest in vehicle. The mice are monitored by investigators and animal care staff for potential signs of toxicity. Because the compound might be novel, the optimal dose will need to be determined in vivo.