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By Stanley Shostak

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S. (2003). Regulation of human breast epithelial stem cells. Cell Proliferation, 36, Suppl 1, pp. 45-58. ; Radovanovic, I. & Ruiz i Altaba, A. (2007). HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell selfrenewal, and tumorigenicity. Current Biology, 17, pp. 165-172. ; Sánchez-García, I. & Pérez-Losada, J. (2008). The Emerging Picture of Human Breast Cancer as a Stem Cell-based Disease. Stem Cell Reviews, 4, pp. 67-79. Cohnheim, J. (1875). Ueber entzundung und eiterung. Path.

In these zones, the endothelial cells that form blood vessels and the specialised basal lamina are essential cellular components of neural stem cell niche (Doetsch, 2003). The niche functions as a physical anchor for stem cells by generating factors that control stem cell proliferation and fate. Calvi & colleagues (2003) demonstrated in bone marrow that osteoblastic cells located in lining of endosteal surface express N-cadherin and physically attach HSCs, thereby acting as a regulatory component with capacity to control the HSCs number.

1999). Hepatic regeneration-revisiting the myth of prometheus. News in Physiological Sciences, 14, pp. 149-155. Bajorath J. (2000). Molecular organization, structural features, and ligand binding characteristics of CD44, a highly variable cell surface glycoprotein with multiple functions. Proteins, 39, pp. 103-111. ; Felszeghy, E. & Piffkó, J. (2002). Gains and losses of adhesion molecules (CD44, E-cadherin, and beta-catenin) during oral carcinogenesis and tumour progression. Journal of Pathology, 198, pp.

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